The role of genetics in pancreatic cancer: Are you at risk?
Published On : 2024-11-22T13:03:53+0530 [ IST ] |
Author : Mayur_Tembhare
Reading Time : 1 mins
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Pancreatic cancer is a highly aggressive disease more common in men usually presents after 60 years and leading to a poor prognosis due to its late-stage diagnosis with a 5-year survival rate ranging from 2% to 9%. According to GLOBOCAN 2022 pancreatic cancer ranks as the 12th most common cancer worldwide while in India it is ranked at 24
Risk factors for PC can be divided into modifiable and non-modifiable risk factors. Among the modifiable risk factors are tobacco smoking excessive alcohol consumption life-style disorders such as obesity dietary habits and exposure to hazardous chemicals. Non-modifiable risk factors attributing to PC include age
Hereditary pancreatitis(HP) is a rare genetic disorder characterized by recurrent acute pancreatitis and chronic pancreatitis that runs in families. The known genetic contributors to familial pancreatitis include pathogenic variants in SPINK1, PRSS1, SPINK1
In pancreatic cancer acquired (somatic) mutations are the primary cause of tumorigenesis. About 90% of PDAC cases have the oncogenic KRAS gene mutation followed by mutations in tumor suppressor genes like TP53 CDKN2A and SMAD4
The failure to repair DNA mismatches in cells creates genomic instability which is a major risk for cancer; therefore these are given with chemotherapy or immunotherapy to enhance better results and reverse resistance.
Other syndromes associated with PC are Familial atypical multiple mole melanoma syndrome (p16/CDKN2A gene) and associated with skin and eye melanomas; Peutz-Jeghers syndrome (STK11 gene) that include increased risks of other cancers. Genetic testing for germline mutations may be useful in families with a history of pancreatic cancer and guide early detection or other related
Author: Dr. Amrit Kaur Kaler Consultant Molecular Pathology Kokilaben Dirubhai Ambani Hospitals Mumbai)
Source : Reporters From Sunrise Chronicles
Tags : According , Amrit Kaur Kaler , Patients , In , Familial , Sotorasib , Other , The , Mutations , mutationstumor suppressor genes like tp53 ,
Summary :
Pancreatic cancer is a highly aggressive disease more common in men usually presents after 60 years and leading to a poor prognosis due to its late-stage diagnosis with a 5-year survival rate rangi
